No one will be placing too much stock into a Week 1 performance, but there is no doubt that teams will be feeling much better at 1-0 rather than 0-1.
Week 2 offers an opportunity to bounce back, but it is also a developing season and that means the key is to avoid falling too far behind those who are going to be pushing for the Playoff.
Thursday Night Football kicks off Week 2 with a big non-Conference game, but there are plenty of good looking games to be played across the weekend.
Detroit Lions @ Buffalo Bills Pick: Thursday Night Football is a feature of the NFL regular season and Week 2 of the 2026 season will see the Buffalo Bills (1-0) open their new home against the Detroit Lions (1-0).
Both teams earned wins in Week 1, although they came in very different fashion.
The Buffalo Bills won on the road against the Houston Texans who are another AFC team expected to push towards the Playoff and it is all the more impressive when you think of the issues Josh Allen has had when facing Houston in the past.
New Head Coach Joe Brady has to be really happy with what he saw from the Bills Offensively, but he will also be aware that there has to be some improvement Defensively if Buffalo are finally going to crack through and reach the Super Bowl.
The Detroit Lions were bigger favourites than the Buffalo Bills in Week 1, but they needed Overtime and then a stop on a two point play to earn the victory against the New Orleans Saints. This is a team that has played well under Head Coach Dan Campbell and one that steps up when they are set as the underdog, but a short week after an Overtime game to open the season places the Lions in a difficult spot.
However, they have to be happy with the way the Offensive Line played in opening up the running lanes and the Lions are going to look to keep the Bills quiet on the sidelines by handing the ball to Jahmyr Gibbs.
Last season the Bills Defensive Line struggled to stop the run, but they have made an encouraging start to the 2026 season. This is a big test for that Line to see where they stand, but failing to stop or slow the run would open up the Secondary to be attacked by Jared Goff and the Detroit passing game.
If the Bills can rush the Quarter Back as they did last week, that will help, but the Detroit Lions should feel they can have some success in Buffalo's new home.
Of course you have to expect plenty of success from Josh Allen and the Buffalo Offensive unit.
There was little wrong with the way the Lions Defensive Line played up front against the run in the win over New Orleans, but the Secondary were banged up last season and Detroit's Defensive Backs struggled in Week 1. Allowing the Saints to put up almost 400 passing yards is not ideal preparation for the Buffalo Bills, although the Lions will feel the pass rush can get into the backfield and at least force the Quarter Back to go through his reads that much quicker than he may want.
Even then, Josh Allen and company should be comfortable moving the ball and this could end up being another shootout as was the case when the teams met in December 2024.
That ended with both teams surpassing the 40 point mark in a game played in Detroit and both Offenses have to believe they can move the ball with confidence in this Week 2 clash in 2026.
The short week should make it that much more difficult for the Defensive units to make the adjustments needed after the issues in Week 1 and that should allow Jared Goff and Josh Allen to lead their team to plenty of successful drives and these two teams may end up surpassing the total points line set.
Minnesota Vikings @ Chicago Bears Pick: Week 1 of the NFL season concluded with three NFC North teams opening at 1-0 and the Minnesota Vikings (1-0) are the reason that the Green Bay Packers were the only team that failed to open with a win.
Since then, the Detroit Lions have dropped to 1-1 and that does mean either the Vikings or the Chicago Bears (1-0) can finish up Week 2 leading the Division as the only unbeaten team (assuming this game will not finish in a tie).
The Vikings were perhaps a little fortunate that the Green Bay Packers capitulated as they did in Week 1 and they will be aware that they will need to be a lot better to beat a Chicago Bears team that have been speaking excitedly about the Offensive unit before the season had begun. An early statement was made by Caleb Williams and the Bears when scoring 59 points in a road win over 2025 NFC South Champions Carolina Panthers, while also putting up over 550 Offensive yards.
No one associated with the Bears can expect to see that kind of output every week, but the Quarter Back has been speaking confidently about the standards Chicago want to set.
They did whatever they wanted against the Carolina Panthers, but this should be a more challenging game against a Minnesota team that had focused on improving the Defensive personnel. Last week the Vikings Defensive Line were able to win at the Line of Scrimmage and prevent the Green Bay Packers from getting consistency from the run game and they will be looking to at least slow a Chicago team that were picking up huge yards on the ground.
However, Caleb Williams will have taken note of the holes that Jordan Love attacked in the Vikings Secondary and the Quarter Back can pick up from there.
Caleb Williams is likely going to be put under some pressure if the team are not able to keep him in third and manageable positions on the field, but he has shown he can move out of the pocket and continue to make plays down the field. Avoiding turnovers is key, but the Bears should be confident they can move the ball with some consistency and that will put the pressure on Minnesota to try and keep up on the scoreboard.
Brian Flores will have his Defensive unit make some plays, but they will need those turnovers to make things easier for an Offense that is going to be led by Carson Wentz rather than Kyler Murray.
A concussion has forced Murray out, but the Minnesota Vikings have an inexperienced Quarter Back coming into the lineup and one who had over 1200 passing yards with 6 Touchdown passes last season.
239 total yards were produced by the Vikings last week as they took advantage of the mistakes made by the Green Bay Packers, but that is asking a lot for that to happen again.
Carson Wentz did have a good game at Quarter Back and the Vikings have talented Receivers who will have seen the Chicago Secondary struggle to make plays last week and that will offer the road team encouragement. The Vikings can also expect a bit more balance in the Offensive play as they are expected to establish the run against a Bears Defensive Line that struggled last season and who have opened up the 2026 season by allowing the Panthers to pick up big yards on the ground.
The Bears will be playing with some revenge on their mind having lost the home opener at Soldier Field to the Minnesota Vikings last year, but they will have a lot of respect for this Divisional rival.
Nothing ever comes easy in the NFL and Chicago cannot expect to be as strong as they were in Week 1, but they may still do enough to force a couple of mistakes from this Vikings Offense and stall some drives. That may be enough to give the Bears the edge and they may just edge past this spread set to move to 2-0 in the Division.
Cleveland Browns @ Tampa Bay Buccaneers Pick: If you know anything about Baker Mayfield, you can guarantee that he has been looking forward to this Week 2 game as soon as the schedule came out in May.
He was the incumbent Quarter Back with the Cleveland Browns (0-1) when the team decided to make a huge trade to bring in Deshaun Watson and that led to Baker Mayfield leaving the team and then ultimately end up with the Tampa Bay Buccaneers (0-1). The Quarter Back has led Tampa Bay to the Playoffs in 2023 and 2024, but injuries made it very tough for Baker Mayfield in 2025, although the decision made by the Browns continues to be one that has them on the wrong side of the trade.
Both teams are looking to bounce back and Baker Mayfield vs Deshaun Watson will be leading the headlines, but the Tampa Bay Buccaneers were a lot more competitive in the Week 1 defeat than the Cleveland Browns.
The Browns Defense may have lost Myles Garrett, but they still have a lot of quality on that side of the field, although winning games will mean needing more from the Quarter Back.
Time definitely feels like it is ticking on the Watson era at Cleveland and it would not be a huge surprise if there is a Quarter Back change during this game if he continues to struggle. Poor decisions were made in the loss at the Jacksonville Jaguars and you do have to wonder if Deshaun Watson will ever reach the levels he had shown with the Houston Texans before the controversy from his personal life ended up impacting his play on the field.
Deshaun Watson has to be better, as he will admit, but he will need support after the Offensive Line struggled in Jacksonville- that was not solely the case in pass protection, but the Browns did not open up the running lanes like the Quarter Back would have wanted and that puts all the pressure on Watson.
Failing to hold onto the ball is on Deshaun Watson, as is the Interception thrown, but there will be some opportunities for him to make plays against this Secondary. However, that will also need his supporting cast to step up and it could be a tough day again on the road for the Cleveland Browns.
They can at least point to the Defensive unit as being able to keep them in this game, but a balanced Tampa Bay approach could still keep Cleveland on their toes.
Last week the Buccaneers showed that balance against the Cincinnati Bengals, although they made too many mistakes on this side of the ball and that ultimately cost them. Cleaning those up should make things easier for the home team, although they will also want to see improvement from the Offensive Line when it comes to protecting Baker Mayfield.
Piling up the points against this Browns team will not be easy, but creating short fields would help and you just know Baker Mayfield is not going to want his team to ease off the throttle if they are in a position to score.
Cleveland cannot really be expected to be as poor as they were in Week 1, but even some improvement may not be enough to keep this game much more competitive when all is said and done. The whole of the Buccaneers team should be motivated as they bid to bounce back from an opening defeat and led by a Quarter Back with a point to prove and that should give Tampa Bay a chance to cover this wide spread.
Philadelphia Eagles @ Tennessee Titans Pick: The opening schedule for the Philadelphia Eagles (1-0) looks pretty testing, but this perhaps the game that looks 'easiest' on paper and it is really important for the team to find a way to motivate themselves.
After opening with a Divisional win, the Eagles will be facing the Chicago Bears, Los Angeles Rams and then travel to London after Week 2 and that means playing in three high-profile spots. With that in mind, it can be easy for players to overlook a team like the Tennessee Titans (0-1) who finished with a 3-14 record in 2025 and who have already been beaten at home by the New York Jets.
A new Head Coach will be hoping he is going to be given some time to help turn things around for the Titans, but Robert Saleh will know he needs some positive signs to just ensure the team back him. In recent years, the Titans have not really been patient with the Head Coach employed, and back to back three win seasons will be hard to surpass considering the schedule and the Division in which they play.
Robert Saleh will need more from Cam Ward at Quarter Back if he is going to guide Tennessee to at least four wins to show some progress, but the sophomore player has to develop quickly. Last season saw some mixed performances from Ward in his rookie season, but there will be a real disappointment about the Week 1 performance from the Quarter Back who threw for just 140 yards against the Jets.
There had been some help offered by the Offensive Line when they set up to run block- the Titans will want to have more than the fourteen attempts from Week 1, but have to be encouraged by picking up almost 5 yards per game. Doing that against this Eagles Defensive Line will be challenging, especially if Cam Ward does not give Philadelphia something more to respect in the passing game.
Last week the Eagles Secondary began the season in good form and it may be difficult for Cam Ward to have a much stronger game than he managed in the loss to the Jets. One positive is that Ward may have more time in the pocket when he does step back to throw, but even that may not be enough reason to believe he can lead the Titans to a lot more successes than they had in the opening defeat.
Philadelphia will definitely be more confident in their ability to establish the run with consistency, although they have lost a key piece of the Line when Landon Dickerson was placed on IR. Those changes will perhaps take some time bedding in and that could allow the Titans to have success at the Line of Scrimmage having rebuilt that part of the Defense around Jeffery Simmons.
Despite that, the Jets were able to get things going on the ground and the Eagles will feel they still have enough about them to do the same.
Jalen Hurts can move the ball with his legs from the Quarter Back position and is still backed up by Saquon Barkley and that may keep the Eagles in front of the chains.
The Quarter Back will be aware that the passing game will be another work in progress after the Eagles traded away AJ Brown, although this whole part of the Offense can be opened up by establishing the run. DeVonta Smith is a very solid Receiver, but it is important for the Eagles to find a consistent performer opposite him if they are going to have a big season.
There should be opportunities for the Eagles to make plays in the passing game and that gives them the edge on the road.
Tennessee will be expecting a much stronger performance after the disappointing effort in Week 1, but they may not be able to get that burst from the Offensive side of the ball that will be needed to earn an upset.
Instead it is perhaps where the Titans will come up short again and that could allow the Philadelphia Eagles to win this one by around a Touchdown mark.
Las Vegas Raiders @ Los Angeles Chargers Pick: If you were to say that one of these AFC West teams would be heading into the Week 2 Divisional clash at 1-0, most would have suggested the Los Angeles Chargers (0-1) would be that team. Instead it is the Las Vegas Raiders (1-0) who travel to the City of Angels unbeaten thanks to a comfortable success over the Miami Dolphins on the same day the Los Angeles Chargers were inexplicably losing at home against the Arizona Cardinals.
The Division is one of the most competitive in the NFL and so the defeat suffered by the Chargers will have really hurt.
The next four games ahead of the Bye Week will see the Los Angeles Chargers face Buffalo, Seattle, Denver and Kansas City and so there is a real pressure on the team to bounce back immediately from the disappointment of Week 1. Back to back eleven win seasons meant the Chargers came into the 2026 season with big expectations on the shoulders of the players to take the next step and have a deep impact in the Playoffs, and that does mean the team need a response.
Las Vegas will make the short journey to Los Angeles in confident mood, but this is a team that is transitioning and that means avoiding throwing Fernando Mendoza straight into action in his rookie season. He was the top Pick in the NFL Draft, but the Raiders will begin the season with Kirk Cousins at Quarter Back and new Head Coach Klint Kubiak has to be really happy with the start made by his team.
This is a big step up for the Raiders who have won seven games across the last two seasons, but who will be looking to surpass the three wins secured in 2025.
Running the ball is going to be tough against this Chargers Defensive Line and that will put a bit more pressure on Kirk Cousins, who had a much more comfortable match up last week.
It is expected that Brock Bowers will miss another game, which is a significant blow for the Raiders passing game, while it is not being disrespectful to say the team are missing a lot of standout Receivers outside of the Tight End. This did not matter against the Dolphins, but Kirk Cousins did not have to do a lot from the Quarter Back position and the veteran may find it tough to exploit the Chargers Secondary without consistent players to throw to.
Kirk Cousins made a couple of mistakes in the win over Miami, and those could be much more costly in a game like this one.
The Raiders have to be prepared to be facing a Chargers team that will have had criticism ringing in their ears following the Week 1 defeat to the Cardinals, but the home fans will expect a reaction.
Justin Herbert leads the Offensive unit that has a new Co-Ordinator in Mike McDaniel, but they did not seem to be in sync in Week 1, which was a real disappointment.
Everything begins at the Offensive Line after the Chargers struggled to establish the run with any consistency in the opening game and that has to change to just open up the playbook for the new Offensive Co-Ordinator to get the best out of the Quarter Back. Much more will be expected of Omarion Hampton and the Offensive Line and they can show a lot more life in this game.
Doing so should make things pretty comfortable for Justin Herbert and the Quarter Back will be looking to take more care of the ball.
One concern for the home team has to be the performance of the Offensive Line to give Justin Herbert time to allow routes to develop down the field and that has to be improved. This is especially the case against the Raiders, who were able to break into the backfield relentlessly in the win over the Dolphins, although it should always be pointed out how poor Miami looked.
There should be some urgency about the Los Angeles Chargers performance and they have won the last four games against this AFC West rival.
It would be a huge surprise if Head Coach Jim Harbaugh has not gotten into his players and cannot extract a reaction from them, while the Las Vegas Raiders are missing the best Receiver and may struggle to move the ball with a lot of consistency. That could come together to see the Chargers secure a solid win and get themselves ready for a four game run that may determine how this season will shape up for them.
MY PICKS: Buffalo Bills-Detroit Lions Over 54.5 Points @ 1.87 Bet365 (1 Unit)
Chicago Bears - 4.5 Points @ 1.91 William Hill (1 Unit)
Tampa Bay Buccaneers - 7.5 Points @ 1.86 Bet365 (1 Unit)
Philadelphia Eagles - 6.5 Points @ 1.83 Bet365 (1 Unit)
Los Angeles Chargers - 6.5 Points @ 1.91 Paddy Power (1 Unit)
Dallas Cowboys - 3.5 Points @ 1.87 Bet365 (1 Unit)
San Francisco 49ers - 13.5 Points @ 1.95 Bet365 (1 Unit)
Week 1: 2-4-1, - 2.23 Units (7 Units Staked, - 31.86% Yield)